Overall Survival

The analysis presented involves the investigation of overall survival (OS) data using Kaplan-Meier survival curves and log-rank tests to evaluate the association between gene, miRNA, and protein expression levels with patient outcomes. Specifically, OS data provided by The Cancer Genome Atlas (TCGA) is used as time-to-event information. The survival time, expressed in days, measures the duration from diagnosis or treatment initiation until the event of interest, such as death or last follow-up.

The expression data used are Gene Expression Quantification HTSeq - FPKM, miRNA Expression Quantification and Protein Expression Quantification

Choice of Time Variables:Users have the flexibility to select the time variable for the analysis based on their specific research needs. The two available options are:

1. OS.time: This variable uses overall survival time data as the primary measure for the time-to-event analysis.
2. DFI.time: This variable utilizes disease-free interval time data, which reflects the duration from diagnosis to the first occurrence of disease recurrence or progression.

The choice between these two time variables can impact the survival analysis results and their interpretations, allowing users to tailor the analysis to their research objectives.

For more details go to PANDA Documentation